Item Number：C3420
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Specification & Item NumberC3420-0100（100ml）;C3420-0020（20ml）
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Storage Conditions-20ºC
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Conditions Carriagedry ice
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Validity Period (Months)15
Product Introduction
The mode of action (MOA) of Penicillin G interferes with the final stage of synthesis of the bacterial cell wall causing disruption of the osmotic pressure gradient across the cell wall with ensuing lysis and cell death, whereas the MOA of streptomycin sulfate modifies the permeability of the cell wall, interferes with prokaryote protein synthesis and cellular respiration by irreversibly binding to the 30S ribosome subunit to cause a misreading/miscoding of the mRNA.
In essence, this activity freezes the 30S initiation complex (i.e.,30S-mRNA-tRNA) and interrupts any further progress in the initiation phase to chain-elongating ribosome. Both antibiotics, penicillin, a β-lactam, when combined with streptomycin, an aminoglycoside, synergistically enhance their range of activities and increase their effectiveness as opposed to when utilized on an individual basis.
The efficacy of the synergistic combination of penicillin-streptomycin is accomplished when the two individual drugs (i.e., both are bactericidal) interfere with two different constituents in the bacterial cellular or metabolic pathways. The result is an effect greater than could be attributed to their additive actions. In theory, a drug affecting the permeability of the cell membrane (i.e., streptomycin), plus a drug affecting the cell wall (i.e., penicillin), when used in combination, may be more effective than either drug used alone.
In essence, this activity freezes the 30S initiation complex (i.e.,30S-mRNA-tRNA) and interrupts any further progress in the initiation phase to chain-elongating ribosome. Both antibiotics, penicillin, a β-lactam, when combined with streptomycin, an aminoglycoside, synergistically enhance their range of activities and increase their effectiveness as opposed to when utilized on an individual basis.
The efficacy of the synergistic combination of penicillin-streptomycin is accomplished when the two individual drugs (i.e., both are bactericidal) interfere with two different constituents in the bacterial cellular or metabolic pathways. The result is an effect greater than could be attributed to their additive actions. In theory, a drug affecting the permeability of the cell membrane (i.e., streptomycin), plus a drug affecting the cell wall (i.e., penicillin), when used in combination, may be more effective than either drug used alone.
Product Application
Penicillin-Streptomycin is an aminoglycoside-β-lactam antibiotic combination solution. It exhibits a broad-spectrum bactericidal activity against both gram-positive and gram-negative bacteria
Production And Quality System
Manufactured under ISO 13485 QMS and in compliance with applicable cGMP guidelines.
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