Item Number：C3430
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Specification & Item NumberC3430-0100 (100ml)；C3430-0020 (20ml)
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Storage Conditions-20ºC
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Conditions Carriagedry ice
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Validity Period (Months)18
Product Introduction
Amphotericin B is a mixture of antimycotic polyenes and is used in cell culture for the control of fungi, yeasts, and molds. These types of antimycotics are typically derived from Streptomyces spp. bacteria. Their mode of action (MOA) is exhibited by their ability to bind to steroidal alcohols (e.g., cholesterol, cholestanol), specifically ergosterol, in the cell membrane of susceptible fungi by creating transmembrane channels in the cell membrane per se thereby increasing membrane permeability. The resultant loss of cations (e.g., K+, Na+, H+) or other low molecular weight substances including sugars, amino acids, or nucleotides, and the inhibitory effect through these channels in the extracellular membrane-bound enzymes contribute to the demise of these types of organisms. Used as a fungicide, it is cytolytic by causing the formation of pores that allow the passage of small molecules through the plasma membrane resulting in cytolysis.
In human medicine, since the introduction of the Echinocandins (i.e., synthetically modified lipopeptides that inhibit the synthesis of β-D-glucan in the fungal cell walls) and the broad-spectrum Azoles, the amphotericin B formulations have seen considerably less use. However, with its long-proven track record, its place in the antifungal armamentarium is ensured.
In human medicine, since the introduction of the Echinocandins (i.e., synthetically modified lipopeptides that inhibit the synthesis of β-D-glucan in the fungal cell walls) and the broad-spectrum Azoles, the amphotericin B formulations have seen considerably less use. However, with its long-proven track record, its place in the antifungal armamentarium is ensured.
Product Application
Amphotericin B is a mixture of antimycotic polyenes and is used in cell culture for the control of fungi, yeasts, and molds.
Production And Quality System
Manufacturing in accordance with cGMP guidelines, in accordance with ISO13485 production standards.
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