Item Number：C3422
-
Specification & Item NumberC3422-0100 (100ml)
-
Storage Conditions-20ºC
-
Conditions Carriagedry ice
-
Validity Period (Months)15
Product Introduction
The mode of action (MOA) of Penicillin G interferes with the final stage of bacterial cell wall synthesis causing disruption of the osmotic pressure gradient across the cell wall with ensuing lysis and cell death, whereas the MOA of streptomycin sulfate modifies the permeability of the cell wall, interferes with protein synthesis and cellular respiration by irreversibly binding to the 30S ribosome subunit to cause a misreading/miscoding of mRNA. In essence, this activity freezes the 30S initiation complex (i.e., 30S-mRNA-tRNA) and interrupts any further progress in the initiation phase to chain-elongating ribosome. Both antibiotics, penicillin combined with streptomycin, synergistically enhance their range of activities and increase their effectiveness as opposed to when they are utilized on an individual basis.
Nystatin is a mixture of anti-mycotic polyenes, like amphotericin B, and is used in cell culture for the control of fungi, yeasts and molds. This polyene macrolide antimycotic, generally termed nystatins, like many other antifungals and antibiotics are of bacterial origin. Nystatin has been isolated from the soil actinomycete, Streptomyces noursei. The mode of action (MOA) of this family is exhibited by its ability to bind to steroidal alcohols (e.g., cholesterol, cholestanol), specifically ergosterol, in the cell membrane of susceptible fungi by creating transmembrane channels in the cell membrane per se thereby increasing membrane permeability.
The resultant loss of cations (e.g., K+, Na+, H+), and/or other low molecular weight substances including sugars, amino acids or nucleotides, the increase or amplification of Na+/K+ pump activity in addition to the inhibitory effect through these channels in the extracellular space of several membrane-bound enzymes, collectively and in concert, all contribute to the demise of these types of organisms.
Nystatin is a mixture of anti-mycotic polyenes, like amphotericin B, and is used in cell culture for the control of fungi, yeasts and molds. This polyene macrolide antimycotic, generally termed nystatins, like many other antifungals and antibiotics are of bacterial origin. Nystatin has been isolated from the soil actinomycete, Streptomyces noursei. The mode of action (MOA) of this family is exhibited by its ability to bind to steroidal alcohols (e.g., cholesterol, cholestanol), specifically ergosterol, in the cell membrane of susceptible fungi by creating transmembrane channels in the cell membrane per se thereby increasing membrane permeability.
The resultant loss of cations (e.g., K+, Na+, H+), and/or other low molecular weight substances including sugars, amino acids or nucleotides, the increase or amplification of Na+/K+ pump activity in addition to the inhibitory effect through these channels in the extracellular space of several membrane-bound enzymes, collectively and in concert, all contribute to the demise of these types of organisms.
Product Application
Penicillin-Streptomycin-Nystatin is an antibiotic combination solution composed of aminoglycoside-β lactam moieties and Nystatin. The aminoglycoside-β lactam combination accords broad-spectrum bacteriocidal activity against both gram-positive and gram-negative bacteria.
Nystatin is primarily fungistatic at low concentrations against biphasic fungi, Dermatophyta and molds. It is also effective against yeasts. These intermolecular hydrogen bonding interactions among the carboxyl, hydroxyl and amino groups stabilize the channel pore causing the cytoplasmic contents to leak out. It may be toxic to some insect cell types.
Nystatin is primarily fungistatic at low concentrations against biphasic fungi, Dermatophyta and molds. It is also effective against yeasts. These intermolecular hydrogen bonding interactions among the carboxyl, hydroxyl and amino groups stabilize the channel pore causing the cytoplasmic contents to leak out. It may be toxic to some insect cell types.
Production And Quality System
Manufacturing in accordance with cGMP guidelines, in accordance with ISO13485 production standards.
Download Product Related Materials
-
Online Message
-
-
Online consultation